1）Project title
China Northwest Cohort Study【Supported by “National Key R&D Program of China. Grant Number: 2017YFC0907200, 2017YFC0907201)”】
2）Project leadership
Hong Yan
3）Project aims
Make full use of the existing cohort research foundation to build a multi-ethnic natural population cohort with good representativeness covering five provinces in Northwest China. Build a unified standard, information sharing database and multi-ethnic biological sample database. Build a fully connected health management system to effectively track end events. To clarify the causal relationship between exposure factors and diseases, to achieve risk assessment and efficient early warning of common and high-risk diseases in the region.
4）Background and good opportunities:
The standards and methods of etiology, prevention, diagnosis and treatment of various diseases based on foreign population research are not fully applicable to Chinese population. In order to further study the health problems of Chinese people, China has successively established a number of large-scale prospective cohort and played an important role in the field of disease research, such as the Chinese chronic disease queue covering 510000 people in 10 provinces. However, the northwest region has unique natural environment, obvious differences in ethnic genetic background, relatively lagging level of economic and social development. The health status and disease characteristics of the population are not only the same as those of the whole country, but also have distinct regional characteristics. Therefore, it is necessary to carry out a large-scale natural population cohort study in the northwest region, in-depth analysis of the relationship between the environment, behavior and lifestyle, genetic factors and common high-risk diseases and health conditions in the region, so as to promote the health of people in the northwest region. At the same time, promote the development of large-scale cohort research and the construction of biomedical big data platform in China, support the development of precision medicine, and promote the realization of "healthy China".
5）Project output and contributions
To formulate a unified and standardized project implementation plan in line with national standards; to build a data network platform for the natural population cohort in the northwest region; to build a biological sample database for the natural population cohort in the northwest region; to carry out baseline survey and initially build the natural population cohort in the northwest region; to explore the organization and management mechanism for the construction of large natural population cohort; To clarify the causal relationship between exposure factors and diseases.
6）Contact information
Hong Yan
7)Representative papers
Zhu Z, Cheng Y, Zeng L, Elhoumed M, He G, Li W, Zhang M, Li W, Li D, Tsegaye S, Chang S,Yan H,Wang EY, Wang D, Jaffar S, Dibley MJ. Association of Antenatal Micronutrient Supplementation With Adolescent Intellectual Development in Rural Western China: 14-Year Follow-up From a Randomized Clinical Trial.JAMA pediatrics2018;172(9): 832-41.
ZengLX.,DibleyMJ., ChengY., DangSN., ChangSY., KongLZ,Yan H. Impact of micronutrient supplementation during pregnancy on birth weight, duration of gestation and perinatal mortality in rural western China:double-blind cluster randomised controlled trial.BMJ. 2008;337:a2001, doi: 10.1136/bmj.a2001 (Published 7 November 2008)
Christian P,Lee SE,Donahue Angel M,Adair LS,Arifeen SE,Ashorn P,Barros FC,Fall CH,Fawzi WW,Hao W,Hu G,Humphrey JH,Huybregts L,Joglekar CV,Kariuki SK,Kolsteren P,Krishnaveni GV,Liu E,Martorell R,Osrin D,Persson LA,Ramakrishnan U,Richter L,Roberfroid D,Sania A,Ter Kuile FO,Tielsch J,Victora CG,Yajnik CS,Yan H,Zeng LX,Black RE. Risk of childhood undernutrition related to small-for-gestational age and preterm birth in low- and middle-income countries.INTERNATIONAL JOURNAL OF EPIDEMIOLOGY.42(5):1340-55. DOI:10.1093/ije/dyt109. OCT 2013(Epub 2013 Aug 6)
Wang XQ,Terry PD,Cheng L,Yan H,Wang JS,Wu WA,Hu SK.Interactions between pork consumption, CagA status and IL-1B-31 genotypes in gastric cancer.WORLD JOURNAL OF GASTROENTEROLOGY.20(25):8151-7. DOI: 10.3748/wjg.v20.i25.8151.JUL 7 2014
Li C, Zeng L, Wang D, Allen S, Jaffar S, Zhou J, Chen T, Watson V,Yan H.Growth in early life and physical and intellectual development at school age: a cohort study.The British journal of nutrition2019; 121(8): 866-76.
